Monitoring oral mucosal microcirculation in healthy volunteers following oral cooling

Monitoring oral mucosal microcirculation in healthy volunteers following oral cooling - OralMicroCryo10

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55691

Enrollment

Registered

2021-05-21

Start date

2021-04-30

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer chemotherapy side effects in oral mucosa Effect of oral cooling on oral mucosa microcirculation effect of oral cryotherapy on oral mucosa microcirculation

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: ASA 1 volunteers • Signed an informed consent form • Volunteers recruited by advertisement >=18 years

Exclusion criteria

Exclusion criteria: • Past history of head and neck malignancy or other relevant pathologies • Previous history of radiation therapy to the head and neck • Volunteers that did not sign an informed consent form • Volunteers

Design outcomes

Primary

Measure	Time frame
Microcirculation measurements before and 30 min after oral cooling; total capillary density (TCD), functional capillary density (FCD), proportion of perfused capillaries (PPC) and microvascular flow index (MFI).	—

Secondary

Measure	Time frame
Mucosal oxygen saturation (StO2) and tissue haemoglobin index (THI) measurements before and 30 min after oral cooling.	—

Countries

Netherlands

Outcome results