Depression Gastric Bypass
Conditions
Interventions
None listed
Sponsors
Maasstadziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age of 18 years and older - The patient uses citalopram daily - The patient is prescribed citalopram at least 2 month before included in the studie, and uses the same dose for at least one week before bloodsampling - The patient is on the waitinglist for a primairy Roux- and Y gastric bypass - The patient is a patient in the Maasstad ziekenhuis or the Franciscus Gasthuis en Vlietland - The patient participates voluntary in the study - The patient has read and understands the information letter and has signed the consent form
Exclusion criteria
Exclusion criteria: - Persons who have previously undergone a bariatric procedure - Persons with an impaired liver and/or kidney function (ALAT> 80 U / l; gamma GT> 100 U / L; MDRD
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AUC (area under serum concentration-time curve) of citalopram three months after surgery compared to baseline at one month before the surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| The following pharmacokinetic parameters of citalopram at one and three months postoperative compared to baseline at one month prior to surgery. - C max (maximal serum concentration) of citalopram - T max (maximal serum concentration) of citalopram - T1/2 (half-life) of citalopram - Trough levels (serum level at time t = 0) of citalopram | — |
Countries
Netherlands
Outcome results
None listed