aneurysmal subarachnoid hemorrhage (aSAH) bleeding between the coverings of the brain due to an aneurysm
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects (n = 14) with aSAH >3 years ago and cognitive impairment - Admitted to the UMCU with aneurysmal SAH at least 3 years ago, defined as o Blood on initial non-contrast CT or bilirubin in cerebrospinal fluid (CSF) o A proven aneurysm, demonstrated by computed tomography angiography (CTA), digital subtraction angiography (DSA) or magnetic resonance angiography (MRA) - Genotyping of rs6971 must show that patient is a high affinity binder - Functional independence (defined as modified rankin scale (mRS) or 0-2) o mRS (Dutch) table can be found in Appendix 1 - Patient must have been at least 18 years of age at time of visit to the outpatient clinic. - Neuropsychological evaluation shows cognitive impairment. Subjects (n = 14) with aSAH >3 years ago and no cognitive impairment - Admitted to the UMCU with aneurysmal SAH at least 3 years ago, defined as o Blood on initial non-contrast CT or bilirubin in CSF o A proven aneurysm, demonstrated by CTA, DSA or MRA - Genotyping of rs6971 must show that patient is a high affinity binder - Functional independence (defined as mRS or 0-2) o mRS (Dutch) table can be found in Appendix 1 - Patient must have been at least 18 years of age at time of visit to the outpatient clinic. - Neuropsychological evaluation shows no cognitive impairment. Controls (n = 8) with unruptured aneurysms - Admitted to the UMCU with an unruptured aneurysm, defined as o A proven aneurysm, demonstrated by CTA, DSA or MRA - Genotyping of rs6971 must show that patient is a high affinity binder - Functional independence (defined as mRS of 0-2) - Patient must have been at least 18 years of age at time of visit to the outpatient clinic. - Neuropsychological evaluation shows no cognitive impairment.
Exclusion criteria
Exclusion criteria: - Contra-indication for PET-MRI scanning (such as severe lower back pain or claustrophobia) - Pregnancy - Exposure to ionic radiation (clinical or experimental) in the past year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All subjects will undergo neuropsychological testing on 5 cognitive domains, and crude test scores will be transformed into z-scores based on scores of a matched control group. . Outcomes will be dichotomized into cognitive impaired or not-cognitive impaired. Furthermore, each subject will be asked to fill out 3 questionnaires to evaluate self-reported cognitive complaints. After this, patients will proceed to undergo 3Tesla brain MRI and 60 minute dynamic Positron Emission Tomography (PET) scanning using a [18F]DPA-714 ligand, where a simplified reference tissue model (SRTM) will be used in quantitation with cerebellar gray matter as pseudo-reference area. Using this method, tracer binding potential (BPND) will be obtained as an estimator of distribution volume ratio (DVR) and differences in BPND between subgroups. It will be investigated if tracer binding potential is correlated with cognitive impairment. Differences in TSPO binding capacity between 3 groups: - Patients with cognitive impairment at least 3 years after aSAH - Patients without cognitive impairment at least 3 years after SAH - Controls with unruptured intracranial aneurysms | — |
Secondary
| Measure | Time frame |
|---|---|
| - Domain and severity of cognitive impairment after SAH - Results of questionnaires - Demographic variables (as listed in paragraph 6.3. Study procedures) - SAH characteristics (as listed in paragraph 6.3. Study procedures). | — |
Countries
Netherlands
Outcome results
None listed