JIA juvenile idiopathic arthritis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
No minimum to 64 Years
Inclusion criteria
Inclusion criteria: For cohorts 1,2 and 3: •
Exclusion criteria
Exclusion criteria: Cohort 1 - Biologic Basis of JIA: * Arthritis explained by any other cause * Joint injections as previous treatment Cohort 2 - Start Biologics: * Arthritis explained by any other cause * Start on biologics as an indication for uveitis only Cohort 3 - : Stop Biologics * Tapering scheme > 12 months to complete biologics stop * Continuing conventional DMARDs beyond the stop of biologics Cohort 4 - Extreme phenotypes *Arthritis explained by another diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| This is a non-interventional, observational cohort study, in which we aim to standardize the assessment of disease activity in all JIA patients at baseline visit, T = 6 months and T= 12 months after start of disease, start of biological therapy and stop of biological therapy. | — |
Secondary
| Measure | Time frame |
|---|---|
| - To develop a disease classification system that categorizes children with arthritis based on their biology and clinical data. - To develop a predictive tool for treatment response to 1st (or subsequent) biological - To develop a predictive tool for successful stop of biological therapy. - To determine disease activity at T= 2 and T =5 years after diagnosis - To determine treatment response at T=2 and 5 year after start of biological therapy - To register severe adverse events in our cohort in the next 5 years. - To assess the current socioeconomic impact of this chronic disease in families with an affected child with JIA. | — |
Countries
Netherlands
Outcome results
None listed