Corneal contour deformation / corneal disease
Conditions
Interventions
With the patient under local anesthesia, the corneal epithelium is removed. The
Bowman graft is immersed in 70% ethanol for 30 seconds to remove remnant
cellular material, thoroughly rinsed with bal
DORC International BV). The Bowman graft is then
carefully positioned onto the host cornea, unfolded, and centered, using a
rigid contact lens to transfer the tissue. Tissue is fixated spontaneously
Sponsors
Melles Hoornvlieskliniek Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Progressive keratoconus, or corneal contour deformation - Indication for a corneal transplant or surgery - 18 years and older - Agree to return for 1 day, 1 week , 1 month, 3 months, 6 months, 9 months, and 12 months post-procedure follow-up visits
Exclusion criteria
Exclusion criteria: - Concomitant ocular disease and/or a contraindication for this type of treatment (e.g. inflammation of the eye, uveitis etc), or any type of circumstances that may be expected to adversely affect the efficacy of the surgery. - Excluded from the study are patients with a severe corneal scarring, e.g. hydrops or contact lens induced opacifications - Severe diabetes - Unable to clearly understand the language used in the clinic (Dutch or English) - Inability to give informed consent for any reason - Pregnant or nursing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Corneal curvature and pachymetry (thickness of the cornea) measured using a Pentacam apparatus and an Anterior Segment Optical Coherence Tomography apparatus (AS-OCT) (standard procedures). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Endothelial cell density, as assessed by specular microscopy and confocal microscopy; - visual acuity, measured by the optometrist using a Snellen chart (standard procedure); - number of complications. | — |
Countries
Netherlands
Outcome results
None listed