specific antibody deficiency
Conditions
Interventions
One-time administration of the 23-valent pneumococcal polysaccharide vaccine.
Sponsors
Sint Antonius Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Age >=18 years and
Exclusion criteria
Exclusion criteria: • Previous vaccination with pneumococcal polysaccharide or conjugate vaccination • Chronic disease that requires the use of immunosuppressive agents • Known or highly suspected primary or secondary immunodeficiency • Pregnancy • Fever or active infection • History of allergic reaction to one of the vaccine components
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Distribution of serotype-specific IgG antibody titers to 13 pneumococcal serotypes four weeks after vaccination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Distribution of serotype-specific IgG antibody titers to 13 pneumococcal serotypes eight weeks after vaccination. Distribution of serotype-specific IgG1, IgG2, IgM and IgA antibody titers to 13 pneumococcal serotypes four and eight weeks after vaccination. Distribution of serotype-specific percent change in IgG, IgG1, IgG2, IgM and IgA antibody titers to 13 pneumococcal serotypes four and eight weeks after vaccination in comparison to pre-vaccination. | — |
Countries
Netherlands
Outcome results
None listed