Protein-specific turnover in the human brain; Measuring protein-specific synthesis rates of the human brain using the D2O dosing method

Protein-specific turnover in the human brain; Measuring protein-specific synthesis rates of the human brain using the D2O dosing method - D2O in Brain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55574

Enrollment

Registered

2017-10-18

Start date

2018-10-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain diseases Temporal Lobe Surgery

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Written informed consent * Male and female patients scheduled for temporal lobectomy * Age 18 - 65 years * Compos mentis

Exclusion criteria

Exclusion criteria: * Comorbidities and neuromuscular disorders of the lower limbs severely interacting with mobility, with limited or no opportunity for improvement (e.g. cerebral palsy) * Peripheral artery disease Fontaine III or IV * Chronic Obstructive Pulmonary Disease (COPD) GOLD III or IV * Use of systemic steroids in the past four weeks, other than indicated for the specific type of surgery * Use of anti-inflammatory biologicals (e.g. TNF-alfa blockers) in the past four weeks * Surgical intervention in the past four weeks * Total parenteral nutrition at day of surgery * Pregnancy * Neoadjuvant chemotherapy or radiotherapy

Design outcomes

Primary

Measure	Time frame
Primary study parameters include protein synthesis rates and enrichments of neocortex, hippocampus, temporalis muscle, and vastus lateralis muscle.	—

Secondary

Measure	Time frame
Secondary parameters include whole-body protein synthesis, breakdown, oxidation, and net balance.	—

Countries

Netherlands

Outcome results