brain tumour Glioma
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Suspected to have a high-grade glioma, for which surgical resection (>=20% of enhancing tumour) is planned Eligible for postoperative chemoradiation 18 years or older Karnofsky performance status of at least 70 Ability to give written informed consent
Exclusion criteria
Exclusion criteria: Prior cerebral surgery or radiation History of vascular brain disease Non-compliance with prescribed anti-seizure medication CNS haemorrhage of Grade > 1 on baseline MRI scan, unless subsequently documented to have resolved Any known metastatic extracranial or leptomeningeal disease Multifocal disease Pregnancy Clinical signs of increased intracranial pressure even under dexamethasone Unwilling or unable to co-operate with breathing manoeuvres Respiratory or cardiac limitations to breathing at 20 L/min Medical contra-indications to limited hypercapnia (known metabolic acidosis or alkalosis) Standard contraindications for 7T MRI scanning, according to MRI guidelines Postoperative pathology results indicating a lesion other than high-grade glioma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The CVR and tissue oxygenation measured on MRI with respiratory challenges within 1 week before surgery, within 1 week after surgery, within 2 weeks before (chemo)radiation and within 1 month after (chemo)radiation will be the main endpoints. | — |
Secondary
| Measure | Time frame |
|---|---|
| Relation of the changes in cerebrovascular reactivity and tissue oxygenation to occurrence and location of postoperative ischemic changes and post-radiation necrosis on routinely acquired clinical MRI scans. | — |
Countries
Netherlands
Outcome results
None listed