Role of cerebral blood flow pulsatility in hypertension related brain damage

Role of cerebral blood flow pulsatility in hypertension related brain damage - HYBRiD-Flow

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55544

Enrollment

Registered

2018-11-22

Start date

2019-07-15

Completion date

Unknown

Last updated

2025-03-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

high blood pressure hypertension

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients with essential hypertension (HTN): - Essential hypertension (defined as an ambulant blood pressure of >= 130 over 80 mmHg) - Age 30-90 years, Normotensive subjects (NT): - Normotensive (ambulant blood pressure of

Exclusion criteria

Exclusion criteria: Patients with essential hypertension (HTN): - Indication of history-taking, physical examination or routine laboratory tests of secondary hypertension - Chronic renal insufficiency (eGFR 50% - Hemorrhagic stroke - Body Mass Index > 32 kg/m² - Inability to provide informed consent - Any contraindication for MRI: metallic implants, pacemaker, claustrophobia, pregnancy, tattoos, permanent make-up. - Contraindications for the gadolinium-containing contrast agent: allergic reaction, eGFR 50% - Hemorrhagic stroke - Body Mass Index > 32 kg/m² - Inability to provide informed consent - Any contraindication for MRI: metallic implants, pacemaker, claustrophobia, pregnancy, tattoos, permanent make-up. - Contraindications for the gadolinium-containing contrast agent: allergic reaction, eGFR

Design outcomes

Primary

Measure	Time frame
- To determine the difference between the intracerebral blood flow pulsatility (in the MCA and LSA) of patients with hypertension and normotensive subjects.	—

Secondary

Measure	Time frame
- To determine the association between hypertension, blood pressure load, cerebral pulsatility and cSVD severity in terms of white matter hyperintensity volume, number of enlarged perivascular lesions, deep infarcts, and cerebral microbleeds. - To determine the relation between cerebral blood flow pulsatility, blood pressure and BBB permeability. - To determine the association between cerebral blood flow pulsatility and brain perfusion. - To determine the relation of the condition of the microcirculation in the retina and cerebral small vessel blood flow in patients with hypertension.	—

Measure

Time frame

- To determine the association between hypertension, blood pressure load, cerebral pulsatility and cSVD severity in terms of white matter hyperintensity volume, number of enlarged perivascular lesions, deep infarcts, and cerebral microbleeds. - To determine the relation between cerebral blood flow pulsatility, blood pressure and BBB permeability. - To determine the association between cerebral blood flow pulsatility and brain perfusion. - To determine the relation of the condition of the microcirculation in the retina and cerebral small vessel blood flow in patients with hypertension.

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Countries

Netherlands

Outcome results