CKD-5D End-Stage-Renal-Disease
Conditions
Interventions
Hemodialysis patients will be treated for 4 weeks using widely used dialysate
solutions as part of standard care containing potassium either 2 mmol/L or 4
mmol/L in random order.
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Adult (age >= 18 years) stable anuric hemodialysis patients that undergo treatment 3 x 4 hrs/week. • Written informed consent
Exclusion criteria
Exclusion criteria: • Pre-dialysis serum potassium 6.0 mmol/L or use of potassium binders • Patients with previous history of ventricular cardiac arrhythmia. • Uncontrolled hypertension (systolic BP >180 mmHg on at least 3 of the last 5 dialysis treatments) or intradialytic hypotension on >3 dialysis treatments in the last month • Patients with insulin dependent diabetes mellitus • Patients with a life expectancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be RBC potassium (mmol/L) | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will include serum potassium, potassium removal, serum sodium, sodium removal, total ultrafiltration volume, total body water, and systolic blood pressure as well as changes in serum bicarbonate, insulin, and plasma aldosterone. | — |
Countries
Netherlands
Outcome results
None listed