Troponin Elevation After Major noncardiac Surgery

Troponin Elevation After Major noncardiac Surgery - TEAMS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55521

Enrollment

650

Registered

2017-11-17

Start date

2018-01-29

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart injury myocardial injury

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Patients are >= 60 years old; - Patients undergo major non-cardiac surgery defined as all non-cardiac surgical procedures requiring an expected hospital stay of at least 24 hours; - Patients undergo elective surgery, defined as surgery that that has been preceded by a preoperative consultation at the anesthesia preoperative screening outpatient clinic.

Exclusion criteria

Exclusion criteria: - Patients unable to fully comply to study needs (e.g. legally incapable patients or patients unable to communicate in Dutch or English). - Patients with an American Society of Anesthesiologists (ASA) Physical status 5

Design outcomes

Primary

Measure	Time frame
Disability is expressed in terms of the WHODAS 2.0 which is based on different functional domains, including cognition, mobility, self-care, getting along, life activities and participation.	—

Secondary

Measure	Time frame
- Disability free survival is defined as being alive with a WHODAS 2.0 score = 25% at 6 months after surgery. - An in-hospital major adverse postoperative events (MAPE), which could be distinguished in: o Major adverse cardiac event (MACE), which is defined as the composite endpoint of cardiovascular death, non-fatal myocardial infarction, non-fatal cardiac arrest, non-fatal ventricular fibrillation, non-fatal ventricular hemodynamic compromise and atrial fibrillation requiring cardioversion. o Noncardiac MAPE, which is defined as a composite outcome consisting of respiratory disorders (including pneumonia and respiratory failure), pulmonary embolism, sepsis and/or systemic inflammatory response syndrome (SIRS), renal failure, reoperation and unplanned ICU admission. - In hospital all-cause mortality - Length of hospital stay - 6-month MACE - 6-month all-cause mortality	—

Measure

Time frame

- Disability free survival is defined as being alive with a WHODAS 2.0 score = 25% at 6 months after surgery. - An in-hospital major adverse postoperative events (MAPE), which could be distinguished in: o Major adverse cardiac event (MACE), which is defined as the composite endpoint of cardiovascular death, non-fatal myocardial infarction, non-fatal cardiac arrest, non-fatal ventricular fibrillation, non-fatal ventricular hemodynamic compromise and atrial fibrillation requiring cardioversion. o Noncardiac MAPE, which is defined as a composite outcome consisting of respiratory disorders (including pneumonia and respiratory failure), pulmonary embolism, sepsis and/or systemic inflammatory response syndrome (SIRS), renal failure, reoperation and unplanned ICU admission. - In hospital all-cause mortality - Length of hospital stay - 6-month MACE - 6-month all-cause mortality

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Countries

Netherlands

Outcome results