Ticking on Pandoras Box: a prospective case-control study into other* tick-borne diseases.

Ticking on Pandora*s Box: a prospective case-control study into *other* tick-borne diseases. - Pandora

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55432

Enrollment

800

Registered

2018-02-13

Start date

2018-06-04

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

virale infectieziekten, Rickettsia infectieziekten, parasitaire aandoeningen Tick-borne diseases (TBD) Tick-borne pathogen (TBP).

Interventions

None listed

Eligibility

Age

16 Years to 99 Years

Inclusion criteria

Inclusion criteria: Cases: - Subjects are 16 years and older; - Subjects report a tick-bite acquired in the last 2 months; - Subjects develop fever (defined as * 38.0 °C) within 4 weeks after the tick-bite; - The temperature is measured rectally, orally, axillary or tympanic; - Subjects do not have evident signs or symptoms of another cause of the fever besides a TBD; - Subjects live or stay in the Netherlands; - Subjects are able to give informed consent and have a thorough command of the Dutch language., Controls: - Subjects are 16 years and older; - Subjects report a tick-bite acquired in the last 2 months; - Subjects do not have a temperature > 37.3 °C within 4 weeks after the tick-bite; - Subjects do not have evident signs or symptoms of any infectious disease; - Subjects live or stay in the Netherlands; - Subjects are able to give informed consent and have a thorough command of the Dutch language.

Exclusion criteria

Exclusion criteria: Cases: Subjects, who - Are 15 years or younger; - Report a tick-bite acquired more than 2 months ago; - Develop fever more than 4 weeks after tick-bite; - Have not measured a temperature over 38.0 °C; - Have evident signs and symptoms pointing towards another cause of the fever than a TBD; - Live or stay outside of the Netherlands during the course of the study; - Are unable to give informed consent or do not have a thorough command of the Dutch language., Controls: Subjects, who - Are 15 years or younger; - Report a tick-bite acquired more than 2 months ago; - Develop a measured temperature * 37.3 °C within 4 weeks after the tick-bite; - Have evident signs or symptoms of any infectious disease; - Live or stay outside of the Netherlands during the course of the study; - Are unable to give informed consent or do not have a thorough command of the Dutch language.

Design outcomes

Primary

Measure	Time frame
1. The prevalence of the different TBDs tested in blood, urine, skin biopsy in a group of participants who develop fever within 4 weeks after tick-bite in the Netherlands, of whom other causes of the fever are excluded. 2. The long term sequelae and the clinical manifestations of the different TBD*s. This will be obtained from the questionnaires and information from the treating specialist(s) and measured by laboratory tests, PCR, serological and culture analyses in both cases and controls	—

Measure

Time frame

1. The prevalence of the different TBDs tested in blood, urine, skin biopsy in a group of participants who develop fever within 4 weeks after tick-bite in the Netherlands, of whom other causes of the fever are excluded. 2. The long term sequelae and the clinical manifestations of the different TBD*s. This will be obtained from the questionnaires and information from the treating specialist(s) and measured by laboratory tests, PCR, serological and culture analyses in both cases and controls

—

Secondary

Measure	Time frame
To obtain clinical isolates of the different TBPs, and other materials from patients with well defined other TBDs, for further research and development/improvement of diagnostic tests.	—

Countries

Netherlands

Outcome results