The effect of transsphenoidal pituitary adenomectomy on macular ganglion cell thickness, post-illumination pupil response, and sleep-wake rhythm

The effect of transsphenoidal pituitary adenomectomy on macular ganglion cell thickness, post-illumination pupil response, and sleep-wake rhythm - PAMPUS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55354

Enrollment

Registered

2018-09-06

Start date

2019-05-29

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pituitary adenoma pituitary tumor

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • 18 years or older • Diagnosis of a pituitary adenoma with optic chiasm compression • Scheduled for elective transsphenoidal adenomectomy (i.e. not in an emergency setting)

Exclusion criteria

Exclusion criteria: • Ocular pathology, other than compressive optic neuropathy, that could influence SD-OCT or pupillometry measurements • Previous intra-ocular surgery • Previous pituitary surgery • Previous radiation in the pituitary area • Diabetes mellitus • Other comorbidity or medication use that could interfere with the study procedures • Inability to give informed consent

Design outcomes

Primary

Measure	Time frame
The main study parameters are the preoperative and postoperative macular ganglion cell-inner plexiform layer (GCIPL) thickness and PIPR measurements.	—

Secondary

Measure	Time frame
• Actigraphy parameters concerning circadian rhythm: interdaily stability, intradaily variability and amplitude • Preoperative and postoperative peripapillary retinal nerve fiber layer (RNFL) thickness • Subjective sleep parameters through questionnaires	—

Countries

Netherlands

Outcome results