Coronary artery disease. Coronary atherosclerosis
Conditions
Interventions
Coronary angiography and OCT assessment of all epicardial vessels (>=2,5 mm)
with intermediate to severe stenosis before and after PCI (if performed). The
use of intracoronary physiology (either FFR
Sponsors
Trialbureau Cardiologie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - 18 years or older - Presenting with non-ST elevation acute coronary syndrome - One or more coronary vessels with intermediate to severe coronary stenosis (30% to 90% by visual estimation or online quantitative coronary analysis (QCA)). - Target vessel with a reference vessel diameter (RVD) >=2.5 and
Exclusion criteria
Exclusion criteria: - Target vessel with a distal Thrombolysis In Myocardial Infarction (TIMI) flow
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study parameter is the association between 3D-angio-based FFR values and OCT detected minimum luminal area pre- and post-PCI. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameters are: (1) The association between 3D-angio-based FFR values and OCT detected causes of luminal obstruction pre-PCI. (2) The association between 3D-angio-based FFR values and OCT detected causes of luminal obstruction post-PCI. (3) Accuracy of 3D-angio-based FFR to detect intraluminal obstructions pre-PCI. (4) Accuracy of 3D-angio-based FFR to detect intraluminal obstructions post-PCI. | — |
Countries
Netherlands
Outcome results
None listed