auditory verbale hallucinations hearing voices
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: BPD patients Patients can participate within the BPD group if they fulfil the following criteria: 1. BPD with the aid of the Structured Clinical Interview for DSM-5 Personality Disorders, 2. Age 18 to 60 years, 3. Persistent AVH in a frequency of at least weekly for a duration of 6 months, 4. Female patients are not pregnant. 5. Patients did not participate in a scientific research study during the last six months involving radiation (or any other form of exposure to the same amount of radiation within the past year via e.g., transatlantic flights), 6. Have no magnetic resonance imaging (MRI)-incompatible implants in the body (such as an insulin-pump, pace-maker, or non-removable piercings). 7. Have no metal particles in their eyes. 8. Have no tattoo*s containing red pigments which could form a safety risk during the MRI-scan, 9. No schizophrenia or schizoaffective disorder 10. No use of methylphenidate or dexamphetamine, haloperidol or valproic acid, carbidopa, glucagon and reserpine, 11. Being able to answer questions, 12. No claustrophobia, 13. Mentally competent. If the diagnoses have been made longer than 4 years prior to inclusion, the SCID 5 and MINI Plus will be used again to confirm the criteria for inclusion. Schizophrenia group: Patients can participate within the schizophrenia group if they fulfil the following criteria: 1. Schizophrenia or schizoaffective disorder, diagnosed with the Mini International Neuropsychiatric Interview Plus, 2. Age 18 to 60 years, 3. Persistent AVH in a frequency of at least weekly for a duration of 6 months, 4. Female patients are not pregnant. 5. Patient did not participate in a scientific research study during the past year involving radiation (or any other form of exposure to the same amount of radiation within the last six months via e.g., transatlantic flights), 6. Have no MRI-incompatible implants in the body (such as an insulin-pump, pace-maker, or non-removable piercings). 7. Have no metal particles in their eyes. 8. Have no tattoo*s containing red pigments which could form a safety risk during the MRI-scan, 9. No BPD, and 10. No use of methylphenidate or dexamphetamine, haloperidol or valproic acid, carbidopa, glucagon and reserpine, 11. Being able to answer questions 12. No claustrophobia, 13. Mentally competent. Patients do not need to be antipsychotic free as antipsychotics do not affect dopamine synthesis (Jauhar et al., 2019). Healthy controls Participants were included in the group of healthy controls if they fulfil the following criteria: 1. No DSM 5 diagnosis of current or past psychiatric disorder or substance dependence other than nicotine dependence, investigated with the SCID-5-PD and MINI Plus, 2. Age 18 to 60 years, 3. No AVH in the last year prior to this study, 4. Female patients are not pregnant. 5. Patient did not participate in a scientific research study during the last six months involving radiation (or any other form of exposure to the same amount of radiation within the past year via e.g., transatlantic flights), 6. Have no MRI-incompatible implants in the body (such as an insulin-pump, pace-maker, or non-removable piercings). 7. Have no metal particles in their eyes. 8. Have no tattoo*s containing red pigments which could form a safety risk during the MRI-scan and 9. No psyc
Exclusion criteria
Exclusion criteria: see inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dopamine synthesis capacity as determined by F-DOPA PET | — |
Secondary
| Measure | Time frame |
|---|---|
| • Positive And Negative Syndrome Scale (Kay et al., 1988) • Questionnaire for Psychotic Experiences (Rosell et al., 2019) • Dissociative Experiences Scale (Bernstein & Putnam, 1986) • Jeugd Trauma Vragenlijst (Bernstein et al., 1997) • Schizotypal Personality Questionnaire (Raine, 1991) • Outcome Questionnaire 45 (Boswell et al., 2013) • Cognitive Biases Questionnaire for psychosis (Peters et al., 2014) • Glutamate and glutamine concentrations • PRAAT language test • Shadowing task | — |
Countries
Netherlands
Outcome results
None listed