coronary plaque Myocardial infarction
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patient >18 years old Patient presented with acute chest pain Patient with positive troponins in blood Patient diagnosed with a non-ST myocardial infarction by cardiologists regardless of the GRACE score (based on the current ESC guidelines) Patient who will undergo invasive coronary angiography within 72 hours after admission (according to ESC guidelines).
Exclusion criteria
Exclusion criteria: - Hemodynamically unstable patients, according to the treating cardiologist - Patients after CABG - Previous STEMI - Previous episode of contrast allergy or anaphylaxis after intravenous iodinated contrast administration - Contra-indications for both adenosine and regadenoson administration - Presence of pacemaker / ICD leads - Renal insufficiency defined as Glomerular Filtration Rate (GFR) 35
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity of index test (CTCA and dynamic stress CTP) to diagnose hemodynamically significant CAD with ICA with intracoronary physiology (FFR/iFR) as reference standard. | — |
Secondary
| Measure | Time frame |
|---|---|
| To estimate the: - Sensitivity and specificity for diagnosis of vulnerable coronary plaques on CTCA with intravascular OCT as reference standard. - Specificity of combined CTCA/dynamic CTP to diagnose hemodynamically significant coronary artery disease on a per patient basis with ICA/FFR as reference standard - Sensitivity and specificity of combined CTCA/dynamic CTP to diagnose hemodynamically significant coronary artery disease on a per vessel basis with ICA/FFR as reference standard - Sensitivity and specificity of mean stress blood flow (MBF) to diagnose hemodynamically significant obstructive CAD with ICA (and FFR/iFR) as reference standard | — |
Countries
Netherlands
Outcome results
None listed