Characterisation of the immune response after spinal cord injury

Characterisation of the immune response after spinal cord injury - The immune response after spinal cord injury

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55320

Enrollment

102

Registered

2021-10-13

Start date

2022-05-24

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Spinal cord injury

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Age >= 18 years - Recently diagnosed with SCI, i.e. not more than 8 weeks prior to admission to the rehabilitation center

Exclusion criteria

Exclusion criteria: - Incapacitated patients - Patients with pre-existing autoimmune disorders - Patients who receive anti-inflammatory or immune modulatory treatment (e.g. corticosteroid administration)

Design outcomes

Primary

Measure	Time frame
- Identification of the autoantibodies produced after SCI. - Characterisation of the autoantibody response after SCI in patients over time. - Assessment of the association between clinical outcome parameters and changes in antibody levels: determining the prognostic biomarker potential of the candidate biomarkers.	—

Secondary

Measure	Time frame
- Determine immune cell subtypes and function, immune derivatives, inflammatory and neurological markers in peripheral blood at multiple time points following spinal cord injury. - Assessment of the association between the clinical outcome parameters and the changes in immunological and neurological parameters in SCI patients.	—

Countries

Netherlands

Outcome results