narrowed heart valve
Conditions
Interventions
None listed
Sponsors
Catharina-ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Age >= 50 years 2. Moderate aortic stenosis confirmed in the past 3 months by standard echocardiographic evaluation: aortic valve area >1.0 cm2 plus either maximal velocity 2.5-3.9 m/s or mean gradient 15-39 mmHg 3. Ability to undergo exercise stress testing 4. Ability to understand and the willingness to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Severe aortic stenosis 2. Percutaneous coronary intervention or coronary artery bypass grafting in the past three months, or have revascularization planned in the near future 3. Known, unrevascularized, and severe coronary artery disease (for example a 90% diameter stenosis or FFR15mm 8. Persistent atrial fibrillation with uncontrolled ventricular response 9. Recent (within 6 weeks) acute coronary syndrome 10. Estimated glomerular filtration rate =2 pulmonary inhalers (note that well-treated and stable asthma and GOLD stage 1 or 2 COPD is permitted) 12. Severe comorbid condition with life expectancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the evaluation of the SAVI metric as a risk predictor compared to standard echocardiographic measurements like AVA and pressure gradient at rest. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints will include correlations between invasive and noninvasive SAVI measurements to explore if stress assessment of the aortic valve can be imaged non-invasively or if it requires invasive hemodynamic measurement. The same will be done with the cardiac CT scans that will be analyzed to see if computational fluid dynamics can simulate invasive SAVI. MRI will provide extra information for cardiac volumes, stroke volume, extracellular volume and grading of hypertrophy. | — |
Countries
Netherlands
Outcome results
None listed