Frailty Aging
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Subjects aged between 55 and 75 years, who are living independently in the city of Amersfoort (the Netherlands) and who understand spoken and written are eligible to participate. All participants will provide written informed consent. After signing informed consent, each participant will first undergo a medical screening by a physician in order to exclude any contra-indications for participation to the test battery. Those who are non-frail at baseline (i.e. robust on three frailty scales: score=0/5 for the Fried phenotype, score
Exclusion criteria
Exclusion criteria: Subjects who are at baseline unable to participate in the assessments due to physical (e.g. unable to stand up or walk) or cognitive impairments (e.g. unable to understand the test instructions and/or Mini Mental State Examination score
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variables: Factors related to trajectories of intrinsic capacity covering 7 physiological systems. Please see sections 6.1.2.1 to 6.1.2.7 of the research protocol for a desription of the physiological systems, the factors and the measurements. Primary outcome: Staying robust or the occurence of frailty when positive on at least one of three instruments (Fried Phenotype, Rockwood Frailty Index, Groningen Frailty Indicator). Please see section 6.1.1 of the research protocol for a description of these instruments for measuring frailty. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additional explanatory variables: Factors related to functional ability and/or (neuro)physiological factors that can explain changes in trajectories of intrinsic capacity. Please see sections 6.1.3.1 to 6.1.3.6 of the research protocol for descriptions of these variables and their measurements. | — |
Countries
Netherlands
Contacts
SOMT University of Physiotherapy