Inflammatory bowel disease
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: - Age of 4-17 years - New patients with a suspicion of IBD or patients with gastrointestinal symptoms who undergo diagnostic work-up (including clinical, laboratory and faecal markers but not necessarily endoscopy) to exclude IBD may be recruited. If a diagnosis is not confirmed after the investigations are complete they will not be followed up any further but any specimens and clinical information can be retained as controls - Written informed consent - Patients have not started IBD treatment yet
Exclusion criteria
Exclusion criteria: - Use of antibiotics or probiotics in the last 3 months prior to inclusion - Use of immunosuppressive therapy prior to the study - Patients diagnosed with immunocompromised disease (any of various diseases that suppress the immune system) - Inability to read and understand the patient and family information sheets (for example insufficient knowledge of national language, where no health advocate of family member is available to translate and ensure full understanding of the study) - Informed consent of patient and/or parents has not been obtained when required
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect to identify IBD-specific microbial and metabolic profiles associated with disease activity, enabling development of clinical decision-making algorithms for earlier detection of paediatric IBD in an intention-to-diagnose population. This would allow for personalized and tailored monitoring of disease activity, timely recognition of exacerbations and prediction of treatment response, improving IBD care. | — |
Secondary
| Measure | Time frame |
|---|---|
| Not applicable. | — |
Countries
Netherlands
Outcome results
None listed