muscle inflammation Myositis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a patient must be adult (>=18 years of age) and suspected of an idiopathic inflammatory myopathy based on signs and symptoms. The latter include: • Symmetrical proximal muscle weakness causing functional limitation to justify treatment with corticosteroids, without significant sensory abnormalities. • Start of symptoms
Exclusion criteria
Exclusion criteria: • Other clear cause for proximal muscle weakness, i.e. the use of myotoxic medication, high suspicion for an inflammatory neuropathy (CIDP) or a positive family history for a hereditary neuromuscular disease • A high suspicion for sporadic inclusion body myositis (sIBM) based on clinical symptoms, including: combination of slow onset of asymmetrically, predominantly distal weakness, atrophy of quadriceps and forearms and age >50 years.3 • High suspicion on a neurogenic cause, based on more severe distal weakness than proximal weakness, asymmetric weakness, fasciculations in >1 region • No availability for follow-up of 6 months • Immunosuppressive treatment • Previous history of myositis • Contraindications for MRI, claustrophobia • No consent for muscle biopsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy of various strategies, taking patient burden into account. | — |
Secondary
| Measure | Time frame |
|---|---|
| Costs of diagnostic tests in the respective testing strategies. | — |
Countries
Netherlands
Outcome results
None listed