Autoimmune inflammation as cause of RelapsIng Symptoms in patients with viral Encephalitis

Autoimmune inflammation as cause of RelapsIng Symptoms in patients with viral Encephalitis - ARISE

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55224

Enrollment

Registered

2019-12-13

Start date

2020-05-15

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

autoimmune encephalitis Inflammation of the brain" Viral encephalitis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All patients, aged >16 yearsor older. with viral encephalitis proven by PCR or serology

Exclusion criteria

Exclusion criteria: - Patients with encephalitis but no viral pathogen - Neurosurgical operation or neurotrauma, in the 3 months previous to the encephalitis episode - Presence of neurosurgical devices in the central nervous system - Insufficient mastery of the Dutch language - Severe cognitive impairment prior to the encephalitis episode

Design outcomes

Primary

Measure	Time frame
- Identify causes of secondary deterioration or failure to improve after viral encephalitis by studying activation of the immune system and production of autoantibodies.	—

Secondary

Measure	Time frame
- Proportion of patients with viral encephalitis that fail to improve or have secondary deterioration - Determine if the delayed inflammatory response of the brain can be predicted by clinical characteristics upon presentation, blood or cerebrospinal fluid tests and cranial imaging.	—

Countries

Netherlands

Outcome results