Identifying motivational alterations associated with cancer-related fatigue: a cross-sectional study in testicular cancer survivors

Identifying motivational alterations associated with cancer-related fatigue: a cross-sectional study in testicular cancer survivors - Motivational aspects of cancer-related fatigue - CROSS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55202

Enrollment

Registered

2019-12-09

Start date

2019-11-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

kanker-gerelateerde vermoeidheid cancer-related fatigue

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: For all participants (healthy and patients): * Written informed consent * Male * Age between 18 and 50 yrs * Sufficient command of the Dutch language (to answer questionnaires) For all patients: * Unilateral orchiectomy * 3 or 4 cycles of BEP or EP treatment regimen

Exclusion criteria

Exclusion criteria: For all participants (healthy and patients): * Presence of acute infection or inflammation on day of testing (body temperature >38) * Current use of prescribed psychotropic, pain or anti-inflammatory drugs * (history of) long-term (> 6 months) daily use of over-the-counter NSAIDs (ibuproven, diclofenac, naproxen) (for patients: besides those used during cancer-treatment) * Current use of over-the-counter corticosteroids, anti-histamic or anti-inflammatory drugs (participants that use corticosteroid moistures or hay-fever drugs are asked to not use it on the testing day) * Obesity (BMI>30) * (history of) metabolic disease (e.g. diabetes) * (history of) cardiovascular events * (history of) neurological or psychiatric symptoms/disease * (history of) chronic inflammatory disease (e.g. rheumatoid arthritis, Crohns disease) * (history of) hypo/hyperthyroide * (history of) chronic pain (>6 months) (for patients before diagnosis) * (history of) chronic fatigue syndrome or fibromyalgia (for patients before diagnosis) * (history of) hypogonadism/ hormonal disturbance or supletion (for patients before diagnosis) For all healthy participants * No severe fatigue (CIS-fatigue

Design outcomes

Primary

Measure	Time frame
* Individual weightings of effort and reward sensitivity, as measured with effort/reward weighting task * Fatigue score as determined by the Checklist Individual Strength (CIS)	—

Secondary

Measure	Time frame
* Subjective mood ratings (including but not limited to fatigue, depressive mood, and anxiety) (All questionnaires are described below) * Plasma cytokine concentration profiles (including but not limited to CRP, TNF, IL-1 and IL-6) Cortisol Awakening Response (CAR) * Potential health-related, stress-related, and psychosocial predictors (All question-naires are described below) * General neurocognitive functioning (Amsterdam Cognition Scan (ACS) for replication of previous studies (Schagen et al 2008, Stouten-Kemperman et al 2015b)	—

Measure

Time frame

* Subjective mood ratings (including but not limited to fatigue, depressive mood, and anxiety) (All questionnaires are described below) * Plasma cytokine concentration profiles (including but not limited to CRP, TNF*, IL-1 and IL-6) * Cortisol Awakening Response (CAR) * Potential health-related, stress-related, and psychosocial predictors (All question-naires are described below) * General neurocognitive functioning (Amsterdam Cognition Scan (ACS) for replication of previous studies (Schagen et al 2008, Stouten-Kemperman et al 2015b)

—

Countries

Netherlands

Outcome results