Fysiologie van natrium- en volumebalans Blood pressure salt-sensitivity
Conditions
Interventions
High salt diet (>200 mmol Na+ daily) for 1 week and low salt diet (
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: All subjects: - Men and women Between 18 and 75 years of age - Office blood pressure >200 mg/L in a morning urine sample / 500 - 3000mg/24 hrs)
Exclusion criteria
Exclusion criteria: - An office blood pressure >140/90 mmHg; - A body mass index >30 kg/m2; - Use of systemic corticosteroids; - Use of NSAIDs > 2 times a week; - A major illness in the past 3 months of any significant chronic medical illness that the Investigator would deem unfavourable enrolment, including chronic inflammatory diseases, excluding the diseases of interest (DM2 and CKD) ; - A history of any type of malignancy within the past 5 years with the expectation of successfully treated basal cell cancer of the skin; - A history of any auto-immune disease ; - A history of cardiovascular disease (in the past 6 months) defined as documented coronary artery disease including myocardial infarction, (un-)stable angina pectoris or acute coronary syndrome, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, cerebrovascular disease including ischemic and haemorrhagic stroke or a subarachnodial bleeding, or peripheral artery disease including aortic aneurysmata; - A history of eye surgery, glaucoma of retinal disorder; - A history, within 3 years, of drug abuse (including benzodiazepines, opioids, amphetamine, cocaine, THC, methamphetamine); - A history of alcoholism and/or drinking more than 3 units of alcohol per day. Alcoholism is defined as an average weekly intake of >21 units for males. One unit is equivalent to 9 g of alcohol: a half-pint (~ 240mL) of beer, 1 glass (125 mL) of wine or 1 (25ml) measure of spirits; - Smoking or use of tobacco products less than 30 days ago; - Any other issue that in opinion of the Investigator could be harmful to the subject or compromise interpretation of the data.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to explore in DKK and CKD patients the effects of dietary sodium on body fluid volume, as measured by BP, weight and bio-impedance measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters are expressed as the effect of salt intake on: - Skin sodium concentration - Microcirculatory changes - Glycosaminoglycan metabolism - Macrophage activation and lymphangiogenesis - Microbiome content | — |
Countries
Netherlands
Outcome results
None listed