subjectieve effecten, cognitief functioneren Performance and mood enhancement in society
Conditions
Interventions
4 times a placebo or 4 times 15 µg of LSD.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Proficient knowledge of the English language * Written Informed Consent * Understanding the procedures and the risks associated with the study. * Age between 18 and 65 years * Absence of any major medical condition as determined by medical examination and laboratory analysis * Absence of any major psychological condition as determined by medical examination * Free from psychotropic medication * Participants must be willing to refrain from taking illicit psychoactive substances during the study. * Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day. * Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. * Normal weight , body mass index (weight/height2) between 18 and 28 kg/m2
Exclusion criteria
Exclusion criteria: * Having used a psychedelic substance (regular dose) such as LSD, psilocybin, ayahuasca, DMT, Salvinorin, Mescaline, MDMA, NBOMe, 2Cs or any other psychedelic drug within the past 3 months. * History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) * Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks) * Pregnancy or lactation * Hypertension (diastolic > 90 mmHg; systolic > 160 mmHg) * Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) * Psychotic disorder in first-degree relatives * Any chronic or acute medical condition * History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*) * For women: no use of a reliable contraceptive * Tobacco smoking (>20 per day) * Excessive drinking (>20 alcoholic consumptions per week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to examine the possible positive mood and positive subjective effects following repeated doses of 15 mcg LSD compared to placebo. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is to examine the possible induced cognitive performance and increase in neuroplasticity following repeated doses of 15 mcg LSD compared to placebo. | — |
Countries
Netherlands
Outcome results
None listed