Determinants of salt taste in healthy volunteers and patients with chronic kidney disease

Determinants of salt taste in healthy volunteers and patients with chronic kidney disease - Human salt taste

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55173

Enrollment

Registered

2020-12-01

Start date

2021-01-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: The patient group: - Adult (>= 18 years) - CKD (eGFR 15-44 ml/min/1.73 m2) The group of healthy volunteers: - Adult (>= 18 years)

Exclusion criteria

Exclusion criteria: The exclusion criteria for the CKD patients: - smoking - any mouth disease - Diabetes mellitus - Use of any of the following drugs: clopidogrel, amiodaron, flecainide, sotalol, propafenon. - intellectual disability The exclusion criteria for the healthy volunteers: - smoking - any mouth disease - Hypertension (difined as office blood pressure > 140/90 mmHg) - Reduced eGFR, albuminuria, or a known kidney disease - Diabetes mellitus - Intellectual disability

Design outcomes

Primary

Measure	Time frame
Salt-sensitivity (as determined by salt taste testing), 24-hour blood pressure, 24-hour urinary excretion of sodium, plasma renin and aldosterone concentrations.	—

Secondary

Measure	Time frame
- To correlate salt sensitivity thresholds to blood pressure, plasma renin and aldosterone levels. - To correlate salt sensitivity thresholds to differences in the salivary proteome. - To correlate salt sensitivity thresholds to the ability to activate ENaC in a heterologous expression system (Xenopus oocytes).	—

Countries

Netherlands

Outcome results