Hookworm Necator americanus
Conditions
Interventions
Four participants will be exposed to 50 Necator americanus (Na) larvae at week
0. Weekly follow up site visits will take place until week 4 after infection.
Afterwards weekly follow up phone calls,
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Subject is aged >= 18 and
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: 1. Any history, or evidence at screening, of clinically significant symptoms, physical signs or abnormal laboratory values suggestive of systemic conditions, such as cardiovascular, pulmonary, renal, hepatic, neurological, dermatological, endocrine, malignant, haematological, infectious, immune-deficient, psychiatric and other disorders, which could compromise the health of the volunteer during the study or interfere with the interpretation of the study results. These include, but are not limited to, any of the following: • positive HIV, HBV or HCV screening tests; • the use of immune modifying drugs within three months prior to study onset (inhaled and topical corticosteroids and oral anti-histamines exempted) or expected use of such during the study period; • having one of the following laboratory abnormalities: ferritine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Detection of hookworm eggs by faeces microscopy (Kato-Katz) at week 12 and 13 post-infection. • Humoral and cellular immunological changes in the first month after exposure to hookworm | — |
Secondary
| Measure | Time frame |
|---|---|
| • Number of adverse events following exposure to hookworm larvae | — |
Countries
Netherlands
Outcome results
None listed