COVID-19 SARS-CoV-2
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All healthcare workers who have symptoms associated with SARS-CoV-2
Exclusion criteria
Exclusion criteria: None
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1 - The association between SARS-CoV-2 serology (IgG / IgM antibodies) with symptom severity and duration of healthcare workers COVID-19 disease severity classification For the initial presentation of patients we will use the severity scale published by the WHO (COVID-19 Interim Guidance 27-5-2020, page 13). Categories are Mild Disease (Symptomatic COVID-19), Moderate Disease (Pneumonia), Severe Disease (severe pneumonia), Critical disease (ARDS or sepsis). Given the nature of our populations. We expect that the majority of the healthcare workers included will be classified as *Mild disease*. As the pandemic is ongoing and we are still learning about potential clinical subcategories, we will continuously assess clinical criteria with experienced physicians and according to international standards. Indicators for disease severity that we will record for all patients include underlying diseases, days since onset of symptoms, cough, maximum measured body temperature, running nose and shortness of breath (a detailed questionnaire is provided as part of the point to point reply). In the hospitalized patients we will also record days of hospitalization, need for oxygen suppletion (in L/min), ICU admittance, need for ventilation and duration of ventilator support, need for rehabilitation after hospital admittance, multi-organ complications (e.g. need for kidney-replacement therapy, creatinine change compared to baseline, cardiac failure), thrombotic complications (and affected organ by thrombosis). | — |
Secondary
| Measure | Time frame |
|---|---|
| 2 - the validation of an in-house serological test for SARS-CoV-2 (IgG / IgM) for persons with mild infection (UMC Utrecht diagnostic objective) 3 - the association between SARS-CoV-2 serology (presence or absence of SARS-CoV-2 IgG antibodies at visit 3), and three immunological host factors: serum inflammatory marker profile, peripheral blood cell and nasal epithelial cell phenotype (UMC Utrecht research objective) 4 - the association of the respiratory microbiome composition in determining the symptom duration in COVID-19 patients (UMC Utrecht research objective) 5 - the percentage of healthcare workers with SARS-CoV-2 who are still contagious 24 hours after the last symptoms have resolved (contributing to the national study on healthcare worker serology) 6 - the percentage of healthcare workers with negative SARS CoV-2 PCR, but with antibodies (IgG / IgM) against SARS CoV-2 (contributing to the national study on healthcare worker serology) | — |
Countries
Netherlands
Outcome results
None listed