Acute heart failure
Conditions
Interventions
Natriuresis guided treatment versus standard of care
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Male of female >= 18 years of age 2. Primary diagnosis of acute/decompensated heart failure as assessed by treating physician a. Acute heart failure de novo or exacerbation of known heart failure and diagnosis is based on criteria in the ESC HF guidelines 3. Requirement of intravenous diuretic use
Exclusion criteria
Exclusion criteria: 1. Dyspnoea primarily due to non-cardiac causes 2. Patients with severe renal failure impairment receiving dialysis or requiring ultrafiltration 3. Inability to follow instructions 4. Previous participation in this study 5. Any medical conditions that may put the patient at risk or influence study results in the investigator's opinion, or that the investigator deems unsuitable for the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Co-primary outcome: total natriuresis after 24-hours first occurrence of heart failure hospitalization or all-cause mortality after 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes: 48- and 72-hour sodium excretion, length of hospital stay, and percentage change in NT-proBNP at 48 and 72 hours Safety endpoint: doubling of serum creatinine at 24- or 48-hours. | — |
Countries
Netherlands
Outcome results
None listed