Major Depressive Disorder mood disturbance
Conditions
Interventions
None listed
Sponsors
Technische Universiteit Eindhoven
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: • Satisfy DSM-5 clinical criteria for MDD (Only acute and subacute duration (0-2 years), for MDD group only) • Unipolar depression (i.e. no bipolar disorder/mania, for MDD group only) • Age: 18-65 (m/f) • Willing and able to provide informed consent and agree that incidental findings are reported
Exclusion criteria
Exclusion criteria: • Concurrent neurological disorders (e.g. epilepsy, stroke, head trauma, etc.) • Current substance or alcohol abuse • History of psychosis, bipolar depression, autism spectrum disorder, attention deficit hyperactivity disorder or (mild) intellectual disability • Contra-indication for MRI: implants, tattoos non-compatible with brain MRI, pregnancy, claustrophobia • Current or previous treatment with electroconvulsive therapy (ECT), deep-brain stimulation (DBS) or transcranial magnetic stimulation (TMS) • More than 3 depressive episodes in the past (for MDD group only) • Has a current episode of MDD or ever had an MDD episode (for healthy control group only)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Hamilton Depression Rating Scale (HDRS) scores - Treatment / medication usage - MRI metrics (varies per MRI modality, an example is volume per region for a T1-weighted scan and fractional anisotropy for diffusion-weighted scans). | — |
Secondary
| Measure | Time frame |
|---|---|
| - Scores of psychometric assessments (e.g. STAI-DY1 - anxiety score) - Scores of cognitive assessments (e.g. average response time for the eye-tracking task) | — |
Countries
Netherlands
Outcome results
None listed