Utrecht Health Project - Utrecht Cardiovascular Cohort (UHP-UCC)

Utrecht Health Project - Utrecht Cardiovascular Cohort (UHP-UCC) - UHP-UCC

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55070

Enrollment

800

Registered

2021-01-20

Start date

2021-01-04

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerosis cardiovascular disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Being a participant of the Utrecht Health Project. • Having a signed written UHP informed consent, allowing follow-up through linkage with registries and sharing information across medical professionals. • Indicated in UHP informed consent to be interested in participating in further research. • Having had blood samples stored in the UHP biobank.

Exclusion criteria

Exclusion criteria: • Receiving major (cardiovascular) surgery, and/or revascularisation therapy and/or transplantation treatment within 3 months after enrolment. • Below the age of 40 years and above 84. • Not willing to give written informed consent for UHP-UCC. • Not allowing incidental findings to be reported. If the patient gives broad consent, the patient allows to be informed about findings that may be important for him/her. If the patient and/or his representative refuse to agree on this, the patient will not be included.

Design outcomes

Primary

Measure	Time frame
For the 1st research question: To what extent does the CVRM risk profile and co-morbid conditions differ between individuals with (UCC-SMART) and without (UHP-UCC) symptoms of heart failure, but with similar levels of echocardiographic structural- and functional measurements? The main outcome is: presence (and absence) of symptomatology belonging to potentially heart failure combined with referral to UMC Utrecht, assessed with the Heart Failure symptoms questionnaire. The main determinants are: CVRM profile and co-morbidity Potential confounders: age, sex, level of left ventricular dimensions and ejection fraction. For the 2nd research question: To what extent does the CVRM profile and co-morbid conditions differ between individuals without cerebral ischemic symptoms (UHP) from those with symptoms of cerebral ischemia (UCC-SMART), given a similar level of carotid structural and functional values? The main outcome is: presence (and absence) of symptomatology belonging cerebral ischemia based on questionnaire data combined with referral to the UMC Utrecht The main determinants are: CVRM profile and co-morbidity Potential confounders: age, sex, level of carotid atherosclerosis. For the 3rd research question: To what extent does Ideal Cardiovascular Health, assessed by 7 cardiovascular health metrics defined by the American Heart Association, differ between those with (UCC-SMART) and without (UHP-UCC) symptoms of CVD, but with similar levels of cardiac, aortic and carotid structural abnormalities? The main outcome is: presence (and absence) of symptomatology belonging vascular disease based on questionnaire data combined with clinical information from GP and/or UMC Utrecht The main determinants are: CVRM profile and co-morbidity Potential confounders: age, sex, level of subclinical disease of the heart, the carotid artery and the aorta. For the 4th research question: To what extent does the CVRM risk profile and co-morbid conditions differ	—

Measure

Time frame

For the 1st research question: To what extent does the CVRM risk profile and co-morbid conditions differ between individuals with (UCC-SMART) and without (UHP-UCC) symptoms of heart failure, but with similar levels of echocardiographic structural- and functional measurements? The main outcome is: presence (and absence) of symptomatology belonging to potentially heart failure combined with referral to UMC Utrecht, assessed with the Heart Failure symptoms questionnaire. The main determinants are: CVRM profile and co-morbidity Potential confounders: age, sex, level of left ventricular dimensions and ejection fraction. For the 2nd research question: To what extent does the CVRM profile and co-morbid conditions differ between individuals without cerebral ischemic symptoms (UHP) from those with symptoms of cerebral ischemia (UCC-SMART), given a similar level of carotid structural and functional values? The main outcome is: presence (and absence) of symptomatology belonging cerebral ischemia based on questionnaire data combined with referral to the UMC Utrecht The main determinants are: CVRM profile and co-morbidity Potential confounders: age, sex, level of carotid atherosclerosis. For the 3rd research question: To what extent does Ideal Cardiovascular Health, assessed by 7 cardiovascular health metrics defined by the American Heart Association, differ between those with (UCC-SMART) and without (UHP-UCC) symptoms of CVD, but with similar levels of cardiac, aortic and carotid structural abnormalities? The main outcome is: presence (and absence) of symptomatology belonging vascular disease based on questionnaire data combined with clinical information from GP and/or UMC Utrecht The main determinants are: CVRM profile and co-morbidity Potential confounders: age, sex, level of subclinical disease of the heart, the carotid artery and the aorta. For the 4th research question: To what extent does the CVRM risk profile and co-morbid conditions differ

—

Secondary

Measure	Time frame
n.v.t.	—

Countries

Netherlands

Outcome results