CABG cardiothoracic surgery
Conditions
Interventions
None listed
Sponsors
Sint Antonius Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: 1. Adult patients *70 years undergoing elective cardiac surgery 2. Frailty, defined by the presence of at least two of the following characteristics: - Impaired gait speed or hand grip strength - Risk for malnutrition - Impaired cognition - Dependent living - Impaired physical functioning - Polypharmacy - Impaired health related quality of life
Exclusion criteria
Exclusion criteria: Patients undergoing emergency cardiac surgery Patients undergoing transcatheter aortic valve replacement or mitral valve repair. Contraindication for morphine and/or oxycodone No informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoints of this study are the pharmacokinetic parameters of morphine, oxycodone and metabolites in blood in frail patients. Pharmacokinetic parameters are clearance , volume of the central compartment, volume of the peripheral compartment, volume of distribution | — |
Secondary
| Measure | Time frame |
|---|---|
| * Pain according to Numeric Rating Scale (NRS) * Postoperative opioid consumption in the first 5 postoperative days * Vital signs by continuous monitoring (SpO2, respiratory rate, blood pressure) * Side effects of opioids (nausea, vomiting, pruritus, constipation) * Delirium according to delirium observation screening (DOS) * Sedation according to sedation observation scale | — |
Countries
Netherlands
Outcome results
None listed