corona disease Covid-19 infection
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: Patients: - Objectified COVID-19 infection for which ICU or hospital admission was necessary at one of the participating hospitals - Age > 18 years - Sufficient command of the Dutch language to follow test instructions and understand questionnaires - Informed consent. Primary caregivers (if present): - Primary caregiver (spouse or close family member who takes care of the patient most) of a participant with COVID-19 infection as described above - Age > 18 years - Sufficient command of the Dutch language to understand questionnaires - Informed consent. Patients subgroup second/third wave : - Objectified COVID-19 infection for which ICU or non-ICU hospital admission was necessary at the MUMC+one of the participating hospitals - Age > 18 years - Sufficient command of the Dutch language to follow test instructions and understand questionnaires - Informed consent - Treated with both dexamethasone and tocilizumab during ICU admission.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: Patients: - objectified cognitive impairments before the hospital admission for the COVID-19 infection - an unexpected incident leading to severe neurological damage occurring after hospital discharge (such as stroke or traumatic brain injury) - contra-indications for MRI scanning (e.g. metal implants, cardiac pacemaker, claustrophobia, pregnancy) -- physical inability to independently travel to one of the participating hospitals (e.g., bedridden patients). Primary caregivers: no exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient-related outcome: participation and quality of life. Caregiver-related outcome: caregiver burden and quality of life. Neurological outcome: MRI abnormalities and neurological symptoms. Neuropsychological outcome: global and domain-specific deficits in cognitive functioning. Emotional outcome: mood and impact of event. Secondary outcomes: subjective complaints in several areas of functioning. | — |
Countries
Netherlands
Outcome results
None listed