GlucoCEST MRI of the brain in healthy volunteers and patients with brain tumours

GlucoCEST MRI of the brain in healthy volunteers and patients with brain tumours - GlucoCEST MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55021

Enrollment

Registered

2021-02-25

Start date

2020-12-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tissues and organs

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Healthy volunteer: - Disease currently not requiring prescription medication - Baseline venous glucose level below 11.0 mmol/L - Age >= 18 years - Signed and dated written informed consent prior to any study-specific procedures Patient: - WHO performance status of 0 or 1 - Baseline venous glucose level below 11.0 mmol/L - Age >= 18 years - Signed and dated written informed consent prior to any study-specific procedures

Exclusion criteria

Exclusion criteria: Healthy volunteer: - Glucose infusion related exclusion criteria: * Diabetes Mellitus type 1 or 2 (self-reported or 2 measurements on separate days of a non-fasting glucose level >11 mmol/L or fasting glucose level >=7,0 mmol/L) * Sickle cell disease or blood iron deficiency (haemoglobin concentration =11.0 mmol/L or a fasting glucose level >=7.0 mmol/L) * Sickle cell disease or blood iron deficiency, with haemoglobin concentration

Design outcomes

Primary

Measure	Time frame
To optimize a glucoCEST protocol for MRI of the brain in healthy volunteers and patients with brain tumours.	—

Secondary

Measure	Time frame
Test-retest reliability will be determined.	—

Countries

Netherlands

Outcome results