atypical hemolytic uremic syndrome, thrombotic microangiopathy
Conditions
Interventions
Blood, urine, and clinical data. No intervention applicable.
Sponsors
Maastricht Universitair Medisch Centrum +
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Males or females at least 18 years of age; - Have acute kidney injury, defined as estimated GFR 500 U/L, and either schistocytes on peripheral blood smear or undetectable haptoglobin), and platelets 180/120 mmHg and impending organ damage secondary to hypertension (at least one of the following: neurologic disease, hypertensive retinopathy grade III and/or IV, left ventricular hypertrophy); OR -- Pregnancy, including 12 weeks postpartum; OR -- Kidney donor recipient; OR -- Systemic auto-immune disease associated with TMA, including systemic sclerosis, systemic lupus erythematosus, anti-phospholipid syndrome; - Have the ability to understand the requirements of the study, provide written informed consent, and comply with the study protocol procedures.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Have secondary causes of hypertensive emergency, including renovascular hypertension, Cushing syndrome, aldosteronism, pheochromocytoma, thyroid disease; - Have a nephropathy not related to thrombosis on kidney biopsy; - Have ADAMTS13 deficiency, defined as ADAMTS13 activity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The prevalence of C-TMA in patients presenting with TMA, either with coexisting conditions or not. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary parameters are based on the clinical course of disease, including hematologic and renal response, refractory TMA, renal recovery, chronic kidney disease, end-stage kidney disease, and death. | — |
Countries
Netherlands
Contacts
Public ContactS.A.M.E.G. Timmermans
Maastricht Universitair Medisch Centrum +
Outcome results
None listed