Ventilation Inflammation Perfusion and Structure in Neonatal Lung patients

Ventilation Inflammation Perfusion and Structure in Neonatal Lung patients - VINyL study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54975

Enrollment

Registered

2019-08-14

Start date

2020-06-05

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchopulmonary dysplasia underdeveloped lungs

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Premature: born before 28 weeks PMA, good enough clinical condition to undergo MRI, parents manage Dutch language, informed consent by parents, at 34-40 weeks still admitted at the Sophia Children's Hospital, (at risk for) severe BPD according to NHI criteria (received at least 28 days of oxygen) Non premature: born after a minimum of 37 weeks PMA, good enough clinical condition to undergo MRI, parents manage Dutch language, informed consent by parents

Exclusion criteria

Exclusion criteria: Premature: contraindication for MRI investigation Non- premature: contraindicatie for MRI investigation, congenital cardiovascular or pulmonary abnormalities, obtained mechanical ventilation

Design outcomes

Primary

Measure	Time frame
The main endpoint of this study is the technical qualitative assessment of the MRIs.	—

Secondary

Measure	Time frame
Second, the ability of the MRI protocol to detect airway and lung ventilation, inflammation, perfusion and structural changes. Third, the MRIs of prematurely born infants will be compared to the MRIs of non- premature patients without pulmonary disease. Lastly, the technical feasibility of MRI to detect cardiac structures will be assessed and the MRI findings will be compared to the EIT measurement.	—

Measure

Time frame

Second, the ability of the MRI protocol to detect airway and lung ventilation, inflammation, perfusion and structural changes. Third, the MRIs of prematurely born infants will be compared to the MRIs of non- premature patients without pulmonary disease. Lastly, the technical feasibility of MRI to detect cardiac structures will be assessed and the MRI findings will be compared to the EIT measurement.

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Countries

Netherlands

Outcome results