electrolyte disorder salt-water disorder
Conditions
Interventions
Targeted correction of plasma sodium concentration in addition to current
standard care during index hospitalisation
Sponsors
Nefrologie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All adult hospitalised patients with hypotonic hyponatremia
Exclusion criteria
Exclusion criteria: • Severe symptomatic hyponatremia in need of intensive care treatment and / or of acute correction with 3% saline • Non-hypotonic hyponatremia with plasma osmolality >300 mOsm • End of life care (palliative treatment) • End stage kidney disease (dialysis) • Acute liver failure • Wernicke encephalopathy • Hepatic encephalopathy during last 2 months • Hepatorenal syndrome • Patients in the isolation ward due to haematological diseases • Pregnancy / breastfeeding • Patients hospitalized for a predetermined fixed duration of 3 days or less (e.g. inpatient chemotherapy treatment)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is the combined risk of death or rehospitalization within 30 days. | — |
Secondary
| Measure | Time frame |
|---|---|
| • Mortality within 30 days and 1 year • Rehospitalization within 30 days and 1 year • Time to death in days • Time to first re-hospitalization in days • Length of index hospital stay in days • Number of falls within 30 days • Number of fractures within 30 days and 1 year • Sodium normalization rate at discharge of index hospitalisation • Change of plasma sodium level from study inclusion until discharge of index hospitalisation • Change of plasma sodium level during the hospitalization • Maximum sodium correction during index hospitalisation • Time in days until first sodium normalization during index hospitalisation • Time in days spent in normonatremia during index hospitalisation | — |
Countries
Netherlands
Outcome results
None listed