long QT syndrome LQTS
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
12 Years to 99 Years
Inclusion criteria
Inclusion criteria: Genetically confirmed LQT1 or LQT2 Age between 12 and 30 years
Exclusion criteria
Exclusion criteria: Pregnancy and post-partum period until the end of breastfeeding The use of hormonal contraceptive therapy other than combined oestrogen-progestin oral contraceptives (i.e. intrauterine contraception, contraceptive vaginal ring, etonogestrel contraceptive implant, injectable contraceptives or progestin pills) History of anorexia nervosa or polycystic ovary syndromeHistory of anorexia nervosa or PCOS BMI for age greater or less than the 99th percentile Double mutation carrier or compound heterozygote Mutations of unknown pathogenicity
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concomitant estradiol and pregnanediol fluctuations will be obtained together with the QTc at three time points during the menstrual cycle or approximately corresponding with the phases of the menstrual cycle in LQTS-females with and without HCT, respectively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Daily QTc fluctuations during 1 month in men and women both with and without HCT. | — |
Countries
Netherlands
Outcome results
None listed