Subarachnoid haemorrhage (SAH): brain damage, cognitive and behavioral functioning as predictors of recovery.

Subarachnoid haemorrhage (SAH): brain damage, cognitive and behavioral functioning as predictors of recovery. - Subarachnoid haemorrhage (SAH): brain injury, cognition and behaviour.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54915

Enrollment

235

Registered

2019-08-22

Start date

2019-11-18

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

intracranial haemorrhage subarachnoid haemorrhage

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. A SAH patient, the diagnosis being based on clinical features in combination with CT angiography (CTA) or digital subtraction angiography (DSA). 2. The patient must be able to understand the instructions of the neuropsychological assessment and be mentally and physically able to undergo the research activities; this will be assessed in a consultation between the treating doctor (neurosurgeon) and researcher (neuropsychologist). 3. Sufficient knowledge of the Dutch language. 4. Age 18 or older

Exclusion criteria

Exclusion criteria: A limited physical and/or cognitive condition which makes it impossible for patients to undergo the neuropsychological assessment and MRI.

Design outcomes

Primary

Measure	Time frame
The primary outcome measure consists of the score on the Impact on Participation and Autonomy (IPA) (Cardol, 2005) questionnaire 1 year after SAH.	—

Secondary

Measure	Time frame
- The score on the IPA 2 years after SAH; - The score on the mRS 1 and 2 years after SAH; - Performance on neuropsychological tests (intelligence, memory, attention, mental speed, language, visuoconstruction skills, executive functions and social cognition); - Scores on questionnaires (complaints, fatigue, anxiety/depression, stress, coping, personality, behavior, quality of life) - Neuro-imaging outcomes (RS-fMRI, DWI, VBM) o ASL/VAI: cerebral blood flow (CBF), cerebral blood volume (CBV), vessel size, oxygen saturation, vessel architecture o DTI: fractional anisotropy (FA) en apparent diffusion coefficient (ADC) o SWI/QSM: affected tissue volume en hemosiderosis volume o Synthetic MRI: quantitative T1, T2, proton density (PD) values.	—

Measure

Time frame

- The score on the IPA 2 years after SAH; - The score on the mRS 1 and 2 years after SAH; - Performance on neuropsychological tests (intelligence, memory, attention, mental speed, language, visuoconstruction skills, executive functions and social cognition); - Scores on questionnaires (complaints, fatigue, anxiety/depression, stress, coping, personality, behavior, quality of life) - Neuro-imaging outcomes (RS-fMRI, DWI, VBM) o ASL/VAI: cerebral blood flow (CBF), cerebral blood volume (CBV), vessel size, oxygen saturation, vessel architecture o DTI: fractional anisotropy (FA) en apparent diffusion coefficient (ADC) o SWI/QSM: affected tissue volume en hemosiderosis volume o Synthetic MRI: quantitative T1, T2, proton density (PD) values.

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Countries

Netherlands

Outcome results