Presepsin as diagnostic marker for bacterial infection in young infants with fever of unknown origin

Presepsin as diagnostic marker for bacterial infection in young infants with fever of unknown origin - Presepsin in young infants with fever

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54911

Enrollment

230

Registered

2021-02-19

Start date

2021-09-14

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bacterial infection sepsis

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - Age under 3 months - Temperature 38,0 °C or higher - Fever of unknown origin - Visiting emergency department from home - Submitted to blood sampling evaluation as part of standard care, i.e. blood culture and/or infection parameters - Informed consent of parent(s) or legal guardian(s)

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
The plasma presepsin level in infants with a bacterial or a viral infection	—

Secondary

Measure	Time frame
- A cut-off value of plasma presepsin level for bacterial infection in young infants - The diagnostic accuracy of presepsin for bacterial infection in young infants, also as compared to currently used infection parameters. - A clinical pattern associated with probable bacterial infection, determined by high and low presepsin levels in young infants in which no pathogen is found.	—

Countries

Netherlands

Outcome results