fatty liver Non-alcoholic fatty liver (NAFL)
Conditions
Interventions
Participants will adhere to two diets differing in GI and SFA content for 2
weeks each: a two-week low GI/low SFA diet and a two-week high GI/high SFA
diet. Diets will be comparable in macronutrient
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Signed informed consent - Caucasian (people will be excluded when having a *50% racial African/Asian background) - Male or postmenopausal female - Aged 45-75 years at start of the study - Body mass index (BMI) 27 * 38 kg/m2 - Stable dietary habits (no weight loss or gain >3kg in the past 3 months) - Sedentary lifestyle (not more than 2 hours of sports per week) - TG between 1.0 and 4.0 mmol/L
Exclusion criteria
Exclusion criteria: - Type 2 diabetes - Any acute condition, exacerbation of chronic condition, or medical history that would in the investigator*s or dependant physician's opinion interfere with the study - Contra-indication for MRI - Alcohol consumption of >2 servings per day - Smoking - Vegetarian, vegan, food intolerant to common foods (e.g. gluten intolerant, lactose intolerant) - Use of medication known to interfere with the safety of study procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver fat content (measured by 1H-MRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| Explorative study parameters: - de novo lipogenesis (DNL) measured as relative contribution of newly synthesized palmitate in the VLDL-TG pool expressed as %DNL. - hepatic fat oxidation measured as plasma beta-hydroxybutyrate (BHB) - hepatic glycogen content (13C-MRS) - substrate oxidation - plasma metabolites related to energy metabolism - liver fat composition (1 H-MRS) - 24h glycemic response | — |
Countries
Netherlands
Outcome results
None listed