Depression and bipolar disorder Gloom, feeling empty
Conditions
Interventions
The investigational product is an online entry platform that is built for this 
study. The elements of three existing intervention components (KOPPsupport, 
Moodpep and Grow-it) will be integrated in this mobile online platform 
accessible through a link that participants receive from the MARIO team. Up to December 2025, the platform comprised three interventions. As of January 2026, KOPPsupport is no longer in use. 
Participants in the intervention groups will be able to choose between the 
interventions and participate in multiple interventions (also to participate in 
parts of an intervention). The MARIO study team will provide information on 
which intervention may be most suitable for the participant (for instance based 
on their age). The first intervention component until December 2025 was KOPPsupport (Woolderink et 
al., 2010) developed by the Trimbos Institute. KOPPsupport is an existing 
psycho-educational program for COPMI and is developed for participants in the 
age of 16-25 years. The duration of the intervention is ~8 weeks. Previously, the intervention worked as follows: 
Participants who register on the MARIO platform and click on the KOPPsupport intervention 
component will be directed towards the KOPPsupport environment and placed in a 
new group with other participants. In KOPPsupport, new groups will start at the 
same time with the intervention component, which is approximately once per 
month. This means that a MARIO participant who wants to participate in the 
KOPPsupport intervention component will have to wait for max. 4 weeks before 
he/she can start with the actual intervention component. From January
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
12 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Child has a parent with a psychiatric disorder, based on parent and/or child report - Child is in the age range of 10 - 26 years - Written informed consent of child and parent (depending on age of the child) - Fluent in Dutch
Exclusion criteria
Exclusion criteria: - Current depressive or BD disorder diagnosis and/or suicidality based on the K-SADS psychiatric interview that was conducted in the telephone interview as part of the online MARIO-screening study (METC number: 2019.486). However, in case of a mild current depressive episode during the MARIO-screening study, we will ask participants who gave permission for future studies if they agree on another K-SADS psychiatric interview (on mood symptoms and suicidality) after a period of 6 months. If they agree, and there is no current mood episode according to the K-SADS psychiatric interview, the participant is able to participate in the MARIO Intervention study. - Not having adequate access to laptop or mobile phone during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PHQ-9 measured with the MARIO-check (administered T0-T3). Of note, for some participants, part of the T0 assessment has already been conducted as part of the MARIO-screening study and those data will be used as baseline data for the intervention study. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Endpoints: * Mania symptoms as measured with the MARIO-check (questions from the General Behavior Inventory (T0-T3) and K-SADS, administered (T0 en T3 if PHQ-9 >4) * Mood diagnosis will be determined by a telephone interview which is conducted at two time points (T0 and T3) using the K-SADS depression and mania sections. The K-SADS at T3 will only be conducted when the PHQ-9 total score is >=5 (indicating mild depressive symptoms (Kroenke, Spitzer & Williams, 2001)) at any of the time points. In case a subject is 18 years or younger, we will also administer the K-SADS by one of the parents. - Mediators (assessed at two or more time points, see Table 1): * Coping assessed with the Utrecht Coping List for Adolescents (UCL-A) * Sleep - Moderators (assessed T0): * child sex and age * parent sex and age * type of parental disorder (based on parent self-report or child report, obtained from the screening study) * age of onset parental disorder (based on parent self-report or child report obtained from the screening study) * number of affected parents (1 versus 2) (based on parent self-report or child report obtained from the screening study) * marital and/or household status of parent (based on parent self-report or child report obtained from the screening study) * income and educational level of parent (based on parent self-report or child report obtained from the screening study) * co-parent mood symptoms (based on parent self-report obtained from the Screening study) | — |
Countries
Netherlands
Contacts
Public ContactA. Vreeker
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed