The MR-Linac Technical Feasibility Protocol For Development of MR-guided Adaptive Radiation Therapy.

The MR-Linac Technical Feasibility Protocol For Development of MR-guided Adaptive Radiation Therapy. - UMBRELLA-2

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON54848

Enrollment

140

Registered

2018-08-24

Start date

2019-01-23

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer malignancy cancer

Interventions

Radiotherapy

Eligibility

Age

16 Years to 64 Years

Inclusion criteria

Inclusion criteria: • Patient, age >= 18 years, treated with radiation therapy on the MR-Linac. • WHO performance 0-2. • Ability to understand and the willingness to sign a written informed consent document.

Exclusion criteria

Exclusion criteria: • Contra-indications for an MRI examination. • Patient is pregnant. • Claustrophobia. • Patients >140 kg and/or a body width > 60 cm.  • Patients with any other clinically significant medical condition which makes it undesirable for the patient to participate in the study or which could jeopardize compliance with study requirements or severe psychiatric  illness/social situation.

Design outcomes

Primary

Measure	Time frame
To test the feasibility of multiple techniques/software for MR-guided adaptive radiotherapy on the Elekta Unity MRL system.	—

Secondary

Measure	Time frame
Treatment associated >= grade 3 acute toxicity according to the NCI Common Terminology Criteria of Adverse Events (CTCAE version 4.03).	—

Countries

Netherlands

Contacts

Public ContactE.A.C. Schouten

Antoni van Leeuwenhoek (AVL)

m.nowee@nki.nl0205129111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: May 1, 2026