Language impairment in the 22q11 deletion syndrome

Language impairment in the 22q11 deletion syndrome - Language impairment in 22q11DS

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54844

Enrollment

210

Registered

2017-10-01

Start date

2019-01-02

Completion date

Unknown

Last updated

2025-09-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

developmental language disorder developmental language impairment

Interventions

None listed

Eligibility

Age

2 Years to 15 Years

Inclusion criteria

Inclusion criteria:  Age: 3-6,5 years Growing up in monolingual, Dutch-speaking families Patient groups: a diagnosis of 22q11 deletion syndrome OR Specific Language  Impairment (which is not strictly a medical condition) Control group: healthy, typically developing children; confirmed absence of any  of the above conditions. 

Exclusion criteria

Exclusion criteria:  severe hearing loss (35 dB or worse) growing up in a family in which one or more other languages in addition to  Dutch are regularly used to communicate with the child 

Design outcomes

Primary

Measure	Time frame
(1) Similarity/ difference in developmental language profiles of children with 22q11DS and children with SLI, in comparison to neurotypical (typically developing) controls. (2a) Similarity / difference of the 22q11DS and SLI groups with respect to neurocognitive mechanisms hypothesized to be critical for language acquisition: short-term/working memory, executive function, and implicit learning. (2b) The degree of association between neurocognitive performance and language outcomes in the 22q11DS and SLI groups.	—

Measure

Time frame

(1) Similarity/ difference in developmental language profiles of children with 22q11DS and children with SLI, in comparison to neurotypical (typically developing) controls. (2a) Similarity / difference of the 22q11DS and SLI groups with respect to neurocognitive mechanisms hypothesized to be critical for language acquisition: short-term/working memory, executive function, and implicit learning. (2b) The degree of association between neurocognitive performance and language outcomes in the 22q11DS and SLI groups.

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Countries

Netherlands

Contacts

Public ContactJR Wignand

Universitair Medisch Centrum Utrecht

3tonderzoek@uu.nl0302535753

Outcome results