Modification of allergenic proteins with glycans for oral tolerance induction

Modification of allergenic proteins with glycans for oral tolerance induction - Modification of allergenic proteins ('GoAllergy')

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54808

Enrollment

Registered

2021-09-28

Start date

2023-09-06

Completion date

Unknown

Last updated

2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute inflammation Food allergy

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - At least 18 years of age - Cow*s milk or peanut allergy based on either 1) positive food challenge, or 2) IgE-sensitization to cow*s milk or peanut (sIgE>0.35 kU/l or positive skin prick test) in combination with a convincing history (reaction with symptoms suggestive of allergy within 2 hours of ingestion of cow*s milk)

Exclusion criteria

Exclusion criteria: - Use of immunosuppressive drugs - Previous or current participation in an allergy immunotherapy trial - Pregnancy

Design outcomes

Primary

Measure	Time frame
This study has several exploratory parameters: 1. The phenotype and function of cows milk/peanut specific T cell lines/clones (Th1, Th2, Th17 and Tregs) determined by extracellular/intracellular T cell markers and cytokines. 2. IgE binding to unmodified and glycan-modified cows milk/peanut proteins/peptides. 3. Antibody production and antibody type of allergen-specific B cells 4. The degranulation of basophils (CD63) 5. The degranulation and maturation of mast cells (beta-hexosaminidase and/or cytokines).	—

Measure

Time frame

This study has several exploratory parameters: 1. The phenotype and function of cow*s milk/peanut specific T cell lines/clones (Th1, Th2, Th17 and Tregs) determined by extracellular/intracellular T cell markers and cytokines. 2. IgE binding to unmodified and glycan-modified cow*s milk/peanut proteins/peptides. 3. Antibody production and antibody type of allergen-specific B cells 4. The degranulation of basophils (CD63) 5. The degranulation and maturation of mast cells (beta-hexosaminidase and/or cytokines).

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Countries

Netherlands

Outcome results