breast cancer
Conditions
Interventions
None listed
Sponsors
Universiteit van Tilburg
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: For PMBC patients: - Diagnosed with breast cancer - Postmenopausal (not having menstruated for at least 1 year) For the norm population: - Aged 18 years or older - Living near one of the OPTIMUM-hospitals for blood draw
Exclusion criteria
Exclusion criteria: For PMBC patients: - Patients with cognitive impairment will not be included because of expected difficulties in completing these questionnaires without assistance. - Patients who are not able to read or write Dutch will be exlcuded, as they are not able to complete the Dutch questionnaire. For the norm population: - Having cognitive impairments which would interfere with completing the questionnaire without assistance (already not included in the LISS panel) - Not being able to read or write Dutch (already not included in the LISS panel) - Ever being diagnosed with a carcinoma, except for basal cell carcinoma of the skin - Another household member is already invited to this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Adherence to the recommendation not to smoke, and adherence to the WCRF lifestyle recommendations (bodyweight; physical activity; limit red and processed meat; limit sugar sweetened drinks; eat wholegrains, vegetables, fruits, and grains; limit fastfood; limit alcohol consumption), and adherence to the recommendation to sleep at least 7 hours per night. Adherence to these recommendations will be assessed by use of questionnaires, such as the *Dutch Healthy Eating Index*, and the *PASE*. The questionnaires also include items on self-reported length and body weight, and include a measuring tape to measure hip- and waist-circumference. The questionnaire also includes detailed instructions to perform a simple functional muscle strength test at home (i.e., Five Times Sit To Stand (5TSTS)). Biological markers include markers related to inflammation (i.e., pro- and anti-inflammatory cytokines (TNFa, IL-6, IL-10, IL-1Ra, CRP), metabolism (i.e., leptin, insulin, insulin growth factor-1, glucose,HbA1C, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, Vitamin D), to breast cancer recurrence risk (i.e., estradiol (total estradiol, free estradiol, estrone, estrone sulfate, dehydroepiandrosterone sulfate (DHEAS), testosterone), cellular aging (leukocyte telomere length), and the kynurenine pathway (including tryptophan, kynurenine, and kynurenic acid). By use of the accelerometer (and the Fitbit in the Fitbit validation), energy usage, metabolic equivalent (MET), physical activity intensity, sedentary and activity bouts, steps taken, total sleep time, sleep latency, wake after sleep onset, and sleep efficiency, will be assessed. Outcome measures of the extra measurement during the second COVID-19 lockdown are physical activity level (self-reported by use of the PASE questionnaire) and sleep pattern (determined by the PSQI). In addition we will directly measure physical activity duration and intensity, total sleep time, number of wakes | — |
Secondary
| Measure | Time frame |
|---|---|
| PMBC patients: The questionnaire assesses *Readiness for lifestyle change* and *Need for support* using 1 item per recommendation. Additionally, also non-changeable determinants (as ethnicity, cancer stage at diagnose) and changeable determinants (as self-efficacy and post-traumatic growth) of adherence to recommendations will be assessed. The norm population: The questionnaire also assesses anxiety and depressive symptoms, health-related quality of life, and physical and mental fatigue. These aspects are also measured among PMBC patients (changeable determinants). | — |
Countries
Netherlands
Outcome results
None listed