Knee osteoarthritis Osteoarthritis of the knee
Conditions
Interventions
Pre-sleep protein supplementation two weeks before TKR, or no intervention.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Written informed consent - Male and female patients scheduled for total knee arthroplasty - BMI between 18.5-35 kg/m2 - Age >18 years - Mentally competent, as judged by the treating physician - Functioning gastrointestinal tract, eligible for oral protein supplementation
Exclusion criteria
Exclusion criteria: - Corticosteroid injections less than 3 months prior to participation - Any medications know to affect protein metabolism (i.e. systemic corticosteroids or prescription strength acne medications) - Lactose intolerance - Insulineafhankelijke diabetes mellitus - Alcohol abuse - Rheumatoid arthritis - Peripheral artery disease Fontaine III or IV - COPD GOLD III or IV - Pheynylketonuria - Surgical intervention to the knee in the past four weeks - Total parenteral nutrition at day of surgery - Neoadjuvant chemotherapy or radiotherapy - GFR
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters include protein synthesis rates and enrichments of Hoffa*s fat pad, synovium, tendon, bone, muscle, ligament, menisci, and cartilage. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary parameters include whole-body protein synthesis, breakdown, oxidation, and net balance. | — |
Countries
Netherlands
Outcome results
None listed