Exploring the Neural Basis of Cognitive Processing in the Human Brain: Single Neuron Recordings in Depth-electrode Candidates for Epilepsy Surgery

Exploring the Neural Basis of Cognitive Processing in the Human Brain: Single Neuron Recordings in Depth-electrode Candidates for Epilepsy Surgery - Single Neuron Recordings in Depth-electrode Candidates

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON54764

Enrollment

Registered

2016-04-07

Start date

2016-06-10

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy seizures

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Epilepsy patients with macro-electrode and micro-wire implants 18 years or older patients able to perform the experiments at an adequate level patients need to be mentally competent

Exclusion criteria

Exclusion criteria: IQ

Design outcomes

Primary

Measure	Time frame
The main study parameters are the macro- and microelectrode recordings of different brain areas during the performance of simple behavioural tasks and during stimulation of macro-electrode contacts. An important goal is to relate performance on the tasks to the neural data.	—

Secondary

Measure	Time frame
The secondary study parameters are the single- and multi-unit recordings and LFP during stimulation of the macro-contacts (if this is performed as part of the clinical assessment) and a functional MRI scan if an electrode is located in a visual area. We will also use data from two self/report questionnaires which will be administered both pre- and post-implantation. We will use the Beck Anxiety Inventory to assess anxiety and the Beck Depressivity Index to assess depression after the operation. These scores can be used to as co-regressors in our neural analyses. We will administer the questionnaire 3-4 days post-operatively to assess the patient*s state during the experimental phase at which we record the majority of our data.	—

Measure

Time frame

The secondary study parameters are the single- and multi-unit recordings and LFP during stimulation of the macro-contacts (if this is performed as part of the clinical assessment) and a functional MRI scan if an electrode is located in a visual area. We will also use data from two self/report questionnaires which will be administered both pre- and post-implantation. We will use the Beck Anxiety Inventory to assess anxiety and the Beck Depressivity Index to assess depression after the operation. These scores can be used to as co-regressors in our neural analyses. We will administer the questionnaire 3-4 days post-operatively to assess the patient*s state during the experimental phase at which we record the majority of our data.

—

Countries

Netherlands

Outcome results