fatty liver disease Non-alcoholic fatty liver disease
Conditions
Interventions
None listed
Sponsors
Maastricht Universitair Medisch Centrum +
Eligibility
Age
2 Years to 17 Years
Inclusion criteria
Inclusion criteria: · Participation in the COACH program · Aged below 18 years
Exclusion criteria
Exclusion criteria: · Steatosis on liver ultrasonography · Elevated liver transaminase levels above two times the upper limit of normal (>44 U/L for girls and > 52 U/L for boys) · Implanted medical devices such as pacemakers or neurostimulators · Metal objects in the body (for instances prosthetics, piercings, metal parts in the eye, permanent eyeliner) · Previous brain surgery · Cardiac arrhythmia · Epilepsy · Claustrofobia · Not wanting to be informed about accidental findings on MRS
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ultrasonographic hepato-renal index and liver fat percentage as determined by magnetic resonance spectroscopy. | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic and anthropometric parameters, to correlate with the measured liver parameters (for example waist-circumference, lipids, blood pressure and glucose metabolism). The goal is to gain more insight into which children can be identified as being at-risk for developing NAFLD based on their cardiometbolic profile. | — |
Countries
Netherlands
Contacts
Public ContactA.C.E. Vreugdenhil
Maastricht Universitair Medisch Centrum +
Outcome results
None listed