Parkinson's disease
Conditions
Interventions
None listed
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for Parkinson's disease patients: -18 years of age or older. -Recently diagnosed idiopathic Parkinson's Disease according to the UK Brain Bank Criteria (
Exclusion criteria
Exclusion criteria: Exclusion criteria for all subjects: -Subjects with contra-indications for a MRI scan as defined in the MRI screenings form of Scannexus (Appendix E), such as claustrophobia or subjects carrying incompatible metallic devices such as pacemakers and certain mechanical valves. -Advanced cognitive impairment (MoCA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint will be the structural and functional changes of the PD brain as compared to HC, which will be assessed on 7T ultra-high field MR images. We will also use quantitative MRI approaches, since this enables us to detect small structural and anatomical differences which cannot be detected on qualitative MRI acquisitions. Our aim is to create a diagnostic tool, based on MRI characteristics, which can distinguish PD patients from HC. | — |
Secondary
| Measure | Time frame |
|---|---|
| A secondary study endpoint will be the detection of differences in imaging characteristics between clinically dissimilar subtypes of PD. We aim to correlate clinical phenotype, genetic characteristics and progression of symptoms to functional and structural MRI variations. This requires a longitudinal follow-up, which enables us to establish in what manner progression of clinical symptoms is related to certain neuroimaging characteristics. Furthermore, our aim is to develop a patient specific prognostic model based on MRI characteristics, which can (partially) predict the disease course for the individual patient. Moreover, we aim to assess the potential of brain-enriched EV miRNAs in blood to distinguish PD from the healthy population. | — |
Countries
Netherlands
Outcome results
None listed